Cancer genetics and epigenetics
In our group we study tumours from the intestinal tract (i.e. colon, and stomach) that sometimes develop when the cell machinery preserving the integrity of the genome, rather like computer spelling programs that detect errors and correct them, is not working properly. When these corrector genes (mutators) are inactivated, the mutations that occur in all normal cells accumulate in large numbers because they are not repaired. This originates a remarkable genomic instability and cancer eventually develops when mutations occur in some cancer genes, such as the oncogenes and tumour suppressor genes. Some of the mutator genes are not inactivated by mutations (mutator mutations) but by epigenetic silencing. This results as a consequence of the disintegration of the epigenetic code, an unexplored process that is strongly associated to aging.
These studies have clinical applications. For instance, many hereditary colon tumours originate by mutations in mutator genes that are transmitted from generation to generation. Molecular diagnosis of the deficient mutator genes determines which members of these families will be affected in the future. Identification of tumours with this kind of genomic instability is also useful to detect familial cancer patients and to predict survival.
Institutions
Bioinformatics expertise:
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Biostatistics (21)
- AIZON (Aizon)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Biomedical Signal Processing and Interpretation (IBEC)
- Biostatistics and Bioinformatics Research Group (UPC)
- Cancer genetics and epigenetics (IGTP)
- Chemometrics for Environmental Omics (CSIC)
- Clinical statistics and biodiversity (UB)
- Compositional and Spatial Data Analysis (UPC)
- Data and Signal Processing Research Group (UVic-UCC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- IN2 Ingeniería de la Información (IN2)
- Mathematical Modeling of Metabolic Processes (UdL)
- Modelling, Identification and Control Engineering (UdG)
- Numerical Genomics - Statistical and population genomics (CRAG)
- Quantitative Psychology. Quantitative and Computational Neuroscience (UB)
- Research Group on Statistics, Econometrics and Health (UdG)
- Science and Engineering of Emerging Systems (URV)
- Sequentia Biotech (SeqBio)
- Statistics and Bioinformatics Research Group (UB)
- Statistics and Bioinformatics Unit (VHIR)
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Comparative Genomics (21)
- Bioinformatics of Genome Diversity (UAB)
- Cancer genetics and epigenetics (IGTP)
- Cancer Genomics Group (VHIO)
- Centre Nacional d'Anàlisi Genòmica CNAG-CRG (CRG)
- Comparative and Functional Genomics Group (UAB)
- Comparative Bioinformatics (CRG)
- Comparative Genomics (UPF, CSIC)
- Comparative Genomics (CRG)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics group of GRIB (UPF, IMIM)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Genetics and Genomics of Vegetable Crops and Rosaceae (CRAG)
- Genomics of Individuality (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Laboratory of Relational Algorithmics, Complexity and Learnability (UPC)
- Mathematical Modeling of Metabolic Processes (UdL)
- Multicellgenome Lab (UPF, UB, CSIC)
- Regulatory Genomics (IGTP)
- Roche Diagnostics (Roche)
- Sequentia Biotech (SeqBio)
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Computational Genomics (39)
- Algorithms, Computational Biology, Complexity and Formal Methods (UPC)
- Bioinformatics of Genome Diversity (UAB)
- Biomedical Genomics (IRB Barcelona)
- Cancer genetics and epigenetics (IGTP)
- Cancer Genomics Group (VHIO)
- Centre Nacional d'Anàlisi Genòmica CNAG-CRG (CRG)
- Clinical Genomics Unit ()
- Comparative Bioinformatics (CRG)
- Comparative Genomics (UPF, CSIC)
- Computational & Mathematical Biology (CRM)
- Computational Biology of RNA processing (CRG)
- Computational Genomics (BSC)
- Computational Genomics Lab @ UB (UB)
- Computational RNA Biology group of GRIB (UPF, IMIM)
- Epigenetics of Endocrine Pancreatic Tumours (IGTP)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics group of GRIB (UPF, IMIM)
- Evolutionary Genomics Lab (UPF, CSIC)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Evolutionary Systems Biology (UPF, CSIC)
- Gene Function and Evolution lab (CRG)
- Genome Data Science (IRB Barcelona)
- Genomic and Epigenomic Variation in Disease (CRG)
- Genomics and Bioinformatics Service (UAB)
- Genomics and Disease (CRG)
- Genomics of Individuality (UPF, CSIC)
- High Content Genomics and Bioinformatics (IGTP)
- Human Genome Diversity Group (UPF, CSIC)
- Information Modeling and Processing (UPC)
- Laboratory of Genetic Ichthyology (UdG)
- Made of Genes (MoG)
- Mathematical Modeling of Metabolic Processes (UdL)
- Molecular Modelling and Bioinformatics (UB, IRB Barcelona)
- Oncology Data Science Group (VHIO)
- Regulatory Genomics (IGTP)
- Sequentia Biotech (SeqBio)
- The CRG Bioinformatics Unit (CRG)
- Translational & Consumer Genomics Unit ()
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Functional Genomics (12)
- Biostatistics and Bioinformatics Research Group (UPC)
- Cancer genetics and epigenetics (IGTP)
- Comparative and Functional Genomics Group (UAB)
- Epigenetics of Endocrine Pancreatic Tumours (IGTP)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- High Content Genomics and Bioinformatics (IGTP)
- LifeSciences Research Unit - CRO ()
- Mechanisms of cancer and cell differentiation (IGTP)
- Multicellgenome Lab (UPF, UB, CSIC)
- Regulatory Genomics (IGTP)
- Sequentia Biotech (SeqBio)
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Genetic Variation Analysis (17)
- Cancer genetics and epigenetics (IGTP)
- Centre Nacional d'Anàlisi Genòmica CNAG-CRG (CRG)
- Clinical Genomics Unit ()
- Compositional and Spatial Data Analysis (UPC)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics Lab (UPF, CSIC)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Evolutionary Systems Biology (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- Genomics of Individuality (UPF, CSIC)
- High Content Genomics and Bioinformatics (IGTP)
- Human Genome Diversity Group (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Sequentia Biotech (SeqBio)
- The CRG Bioinformatics Unit (CRG)
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Integrative Bioinformatics (18)
- Bioinformatics Platform (IDIBAPS)
- Cancer genetics and epigenetics (IGTP)
- Computer-aided Drug Design and Knowledge Management (ESTEVE)
- Costaisa (Costaisa)
- Epigenetics of Endocrine Pancreatic Tumours (IGTP)
- Genome Data Science (IRB Barcelona)
- Hereditary Cancer Group (IGTP)
- High Content Genomics and Bioinformatics (IGTP)
- High Performance Computing Applications for Science and Engineering - Bioinformatics (UAB)
- IN2 Ingeniería de la Información (IN2)
- Information Modeling and Processing (UPC)
- Integrative Biomedical Informatics group of GRIB (UPF, IMIM)
- Integrative Systems Biology, Metabolomics and Cancer (UB)
- Mathematical Modeling of Metabolic Processes (UdL)
- Sequentia Biotech (SeqBio)
- Soft Computing (UPC)
- Statistics and Bioinformatics Research Group (UB)
- Statistics and Bioinformatics Unit (VHIR)
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Structural Bioinformatics (20)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Biological Chemistry and Biotechnology Group (URL)
- Cancer genetics and epigenetics (IGTP)
- Computational and Theoretical Chemistry (CSIC)
- Computational continuum mechanics (UPC)
- Computational Science group of GRIB (UPF, IMIM)
- Electronic and Atomic Protein Modelling (BSC)
- Functional Proteomics (UAB)
- Gene Function and Evolution lab (CRG)
- GPCR Drug Discovery group of GRIB (UPF, IMIM)
- Laboratory of Computational Medicine (UAB)
- Modeling of Biological systems & Drug Design (UB)
- Molecular Biotechnology Centre (UPC)
- Nostrum Biodiscovery ()
- Protein Engineering Laboratory (UdG)
- Protein Folding and Conformational Diseases (UAB)
- Protein Interactions and Docking (BSC)
- Structural BioInformatics group of GRIB (UPF, IMIM)
- Structural Informatics & Network Biology (IRB Barcelona)
- Translational Bioinformatics group (VHIR)