Functional Genomics group of GRIB
The Functional Genomics group aims at narrowing the gap between sequence and function by developing computational tools to build network models of molecular regulatory mechanisms from high-throughput genetics and genomics data. The group is interested in the problem of reverse-engineering the genotype-phenotype map trying to embrace the complexity that follows from the coordinated action of genes and other molecules by means of multivariate statistical models, such as graphical Markov models.
The Functional Genomics group of GRIB, led by Robert Castelo, is integrated in the Research Programme on Biomedical Informatics, GRIB. The GRIB is a joint research programme of the Hospital del Mar Medical Research Institute (IMIM) and the Department of Experimental and Health Sciences of the Universitat Pompeu Fabra. The GRIB mission is to develop and apply computational methods and information technologies for a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases, their prevention, diagnosis and pharmacological treatment.
Main projects
-
1.
Limited-order graphical Markov models in integrative genomics (LOGx)
2016-2018. (TIN2015-71079-P) MINECO.
-
2.
European Cooperation for Statistics of Network Data Science (COSTNET)
2016-2019 (CA15109) EU Framework Programme H2020
Institutions
Bioinformatics expertise:
-
Biomedical Informatics (46)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Bioinformatics Core Unit (CRAG)
- Biomedical Genomics (IRB Barcelona)
- Biomedical Signal Processing and Interpretation (IBEC)
- Biostatistics and Bioinformatics Research Group (UPC)
- BITAC (BITAC)
- Centre Nacional d'Anàlisi Genòmica CNAG-CRG (CRG)
- Clinical statistics and biodiversity (UB)
- Computational & Mathematical Biology (CRM)
- Computational Bioinformatics Node (National Institute of Bioinformatics - INB) (BSC)
- Computational Biology & Drug Design (UB)
- Computational Biology and Complex Systems Group (UPC)
- Computational Biology of RNA processing (CRG)
- Computational RNA Biology group of GRIB (UPF, IMIM)
- Control Engineering and Intelligent Systems (UdG)
- Costaisa (Costaisa)
- Data and Signal Processing Research Group (UVic-UCC)
- Disease Genomics (IGTP)
- Distributed Computation Group (UdL)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genomics and Bioinformatics Service (UAB)
- Hereditary Cancer Group (IGTP)
- Information Modeling and Processing (UPC)
- Information System for Research in Primary Care (IDIAP Jordi Gol)
- Institute for Innovation and Knowledge Management (ESADE)
- Integrative Biomedical Informatics group of GRIB (UPF, IMIM)
- Integrative Systems Biology, Metabolomics and Cancer (UB)
- Laboratory of Relational Algorithmics, Complexity and Learnability (UPC)
- Laboratory of Systems Pharmacology and Bioinformatics (UAB)
- Mathematical Modeling of Metabolic Processes (UdL)
- Mechanics of development and disease (IBEC)
- Mechanisms of cancer and cell differentiation (IGTP)
- Mind the Byte ()
- Modeling of Biological systems & Drug Design (UB)
- Modelling, Identification and Control Engineering (UdG)
- Molecular Modelling and Bioinformatics (UB, IRB Barcelona)
- Pharmacelera ()
- Research Group on Artificial Intelligence (URV)
- Roche Diagnostics (Roche)
- Soft Computing (UPC)
- Systems Pharmacology group of GRIB (UPF, IMIM)
- The Computational Chembiological Team (UAB)
- The CRG Bioinformatics Unit (CRG)
- The Human Microbiome Lab (VHIR)
- Theoretical Chemistry, Modelling and Molecular Engineering (UdG)
- Translational Bioinformatics group (VHIR)
-
Biostatistics (21)
- AIZON (Aizon)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Biomedical Signal Processing and Interpretation (IBEC)
- Biostatistics and Bioinformatics Research Group (UPC)
- Cancer genetics and epigenetics (IGTP)
- Chemometrics for Environmental Omics (CSIC)
- Clinical statistics and biodiversity (UB)
- Compositional and Spatial Data Analysis (UPC)
- Data and Signal Processing Research Group (UVic-UCC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- IN2 Ingeniería de la Información (IN2)
- Mathematical Modeling of Metabolic Processes (UdL)
- Modelling, Identification and Control Engineering (UdG)
- Numerical Genomics - Statistical and population genomics (CRAG)
- Quantitative Psychology. Quantitative and Computational Neuroscience (UB)
- Research Group on Statistics, Econometrics and Health (UdG)
- Science and Engineering of Emerging Systems (URV)
- Sequentia Biotech (SeqBio)
- Statistics and Bioinformatics Research Group (UB)
- Statistics and Bioinformatics Unit (VHIR)
-
Functional Genomics (12)
- Biostatistics and Bioinformatics Research Group (UPC)
- Cancer genetics and epigenetics (IGTP)
- Comparative and Functional Genomics Group (UAB)
- Epigenetics of Endocrine Pancreatic Tumours (IGTP)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- High Content Genomics and Bioinformatics (IGTP)
- LifeSciences Research Unit - CRO ()
- Mechanisms of cancer and cell differentiation (IGTP)
- Multicellgenome Lab (UPF, UB, CSIC)
- Regulatory Genomics (IGTP)
- Sequentia Biotech (SeqBio)
-
Genetic Variation Analysis (17)
- Cancer genetics and epigenetics (IGTP)
- Centre Nacional d'Anàlisi Genòmica CNAG-CRG (CRG)
- Clinical Genomics Unit ()
- Compositional and Spatial Data Analysis (UPC)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics Lab (UPF, CSIC)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Evolutionary Systems Biology (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- Genomics of Individuality (UPF, CSIC)
- High Content Genomics and Bioinformatics (IGTP)
- Human Genome Diversity Group (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Sequentia Biotech (SeqBio)
- The CRG Bioinformatics Unit (CRG)
-
Systems Biology and Networks (27)
- Algorithms, Computational Biology, Complexity and Formal Methods (UPC)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Bioinformatics Core Unit (CRAG)
- Bioinformatics Platform (IDIBAPS)
- Biological Chemistry and Biotechnology Group (URL)
- Computational Biology and Complex Systems Group (UPC)
- Computational Biology of RNA processing (CRG)
- Computational Science group of GRIB (UPF, IMIM)
- Control Engineering and Intelligent Systems (UdG)
- Data and Signal Processing Research Group (UVic-UCC)
- Evolution of Insect Metamorphosis (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- Integrative Systems Biology, Metabolomics and Cancer (UB)
- Laboratory of Systems Pharmacology and Bioinformatics (UAB)
- Mathematical Modeling of Metabolic Processes (UdL)
- Molecular Modelling and Bioinformatics (UB, IRB Barcelona)
- Nonlinear dynamics, nonlinear optics and lasers (UPC)
- Nutrition, Eumetabolism and Health (UdG)
- Science and Engineering of Emerging Systems (URV)
- Sequentia Biotech (SeqBio)
- Statistics and Bioinformatics Unit (VHIR)
- Structural BioInformatics group of GRIB (UPF, IMIM)
- Structural Informatics & Network Biology (IRB Barcelona)
- The CRG Bioinformatics Unit (CRG)
- Theoretical Chemistry, Modelling and Molecular Engineering (UdG)
- UPC Dinamical Systems (UPC)
-
Transcriptomics (18)
- Bioinformatics and Biomedical Signals Laboratory (UPC)
- Bioinformatics Platform (IDIBAPS)
- Comparative Genomics (UPF, CSIC)
- Compositional and Spatial Data Analysis (UPC)
- Computational Genomics Lab @ UB (UB)
- Computational RNA Biology group of GRIB (UPF, IMIM)
- Evolution of Insect Metamorphosis (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics group of GRIB (UPF, IMIM)
- Functional Genomics group of GRIB (UPF, IMIM)
- High Content Genomics and Bioinformatics (IGTP)
- LifeSciences Research Unit - CRO ()
- Mathematical Modeling of Metabolic Processes (UdL)
- Multicellgenome Lab (UPF, UB, CSIC)
- Regulatory Genomics (IGTP)
- Sequentia Biotech (SeqBio)
- Statistics and Bioinformatics Research Group (UB)
- Statistics and Bioinformatics Unit (VHIR)
Bioinformatics services offered
-
qpgraph
Estimation of genetic and molecular regulatory networks from high-throughput genomics data
-
VariantFiltering
Filtering of coding and non-coding genetic variables
-
GSVA
Gene Set Variation Analysis for microarray and RNA-seq data