
Centre Nacional d'Anàlisi Genòmica (CNAG-CRG)
The CNAG's mission is to carry out projects in DNA sequence analysis in collaboration with the Spanish, European and International Research Community. Since the 1st July 2015 the CNAG is integrated with the CRG. The center has one of the largest DNA sequencing capacities in Europe (1000 Gbases of sequencing data per day), and an extensive informatics infrastructure.
The CNAG focuses its research efforts on the development of analytical and bioinformatic tools for next generation sequencing and on the analysis and interpretation of genome information in areas such as cancer genetics, rare disorders, host-pathogen interactions, the preservation of endangered species, evolutionary studies, 3D genomics, epigenomics and improvement of species of agricultural interest. Researchers at CNAG participate in major national and international collaborative research projects in genome research such as ICGC, IRDiRC, GA4GH, ELIXIR and IHEC.
Main projects
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1.
RD-CONNECT
RD-Connect is a global infrastructure project funded by EU that links genomic data with registries, biobanks, and clinical bioinformatics tools to produce a central research resource for rare diseases (RD). Within this project, the CNAG has developed a highly sophisticated system to combine data from different ‑omics levels in order to facilitate gene and biomarker discovery through efficient annotation systems and expert systems able to extract knowledge from data.
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2.
B-CAST
The EU funded B-CAST project aims to generate new data on molecular characterisation of ~20,000 tumours from large-scale epidemiological studies, clinical studies and biobanks. The data will be utilised in a statistical model to calculate individualised risk scores to develop certain (sub) types of breast cancer.
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3.
4D-GENOMES
The aim of this ERC-Synergy project is to study the conformation of the genome at various integrated levels, from the nucleosome fiber to the distribution of chromosomes territories in the nuclear space, and to explore whether the genome 3D structure acts as an information source for modulating transcription in response to external stimuli.
http://www.crg.eu/en/content/research/4dgenome-erc-synergy-project
Institutions
Bioinformatics expertise:
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Biomedical Informatics (45)
- Bioinformatics and Medical Statistics (UVic-UCC)
- Bioinformatics Core Unit (CRAG)
- Biomedical Genomics (IRB Barcelona)
- Biomedical Signal Processing and Interpretation (IBEC)
- Biostatistics and Bioinformatics Research Group (UPC)
- BITAC (BITAC)
- Centre Nacional d'Anàlisi Genòmica (CRG)
- Clinical statistics and biodiversity (UB)
- Computational & Mathematical Biology (CRM)
- Computational Bioinformatics Node (National Institute of Bioinformatics - INB) (BSC)
- Computational Biology & Drug Design (UB)
- Computational Biology and Complex Systems Group (UPC)
- Computational Biology of RNA processing (CRG)
- Computational RNA Biology group of GRIB (UPF, IMIM)
- Control Engineering and Intelligent Systems (UdG)
- Costaisa (Costaisa)
- Data and Signal Processing Research Group (UVic-UCC)
- Disease Genomics (IGTP)
- Distributed Computation Group (UdL)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genomics and Bioinformatics Service (UAB)
- Hereditary Cancer Group (IGTP)
- Information System for Research in Primary Care (IDIAP Jordi Gol)
- Institute for Innovation and Knowledge Management (ESADE)
- Integrative Biomedical Informatics group of GRIB (UPF, IMIM)
- Integrative Systems Biology, Metabolomics and Cancer (UB)
- Laboratory of Relational Algorithmics, Complexity and Learnability (UPC)
- Laboratory of Systems Pharmacology and Bioinformatics (UAB)
- Mathematical Modeling of Metabolic Processes (UdL)
- Mechanics of development and disease (IBEC)
- Mechanisms of cancer and cell differentiation (IGTP)
- Mind the Byte (MTB)
- Modeling of Biological systems & Drug Design (UB)
- Modelling, Identification and Control Engineering (UdG)
- Molecular Modelling and Bioinformatics (UB, IRB Barcelona)
- Pharmacelera (Pharmacelera)
- Research Group on Artificial Intelligence (URV)
- Roche Diagnostics (Roche)
- Soft Computing (UPC)
- Systems Pharmacology group of GRIB (UPF, IMIM)
- The Computational Chembiological Team (UAB)
- The CRG Bioinformatics Unit (CRG)
- The Human Microbiome Lab (VHIR)
- Theoretical Chemistry, Modelling and Molecular Engineering (UdG)
- Translational Bioinformatics group (VHIR)
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Comparative Genomics (21)
- Bioinformatics of Genome Diversity (UAB)
- Cancer genetics and epigenetics (IGTP)
- Cancer Genomics Group (VHIO)
- Centre Nacional d'Anàlisi Genòmica (CRG)
- Comparative and Functional Genomics Group (UAB)
- Comparative Bioinformatics (CRG)
- Comparative Genomics (UPF, CSIC)
- Comparative Genomics (CRG)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics group of GRIB (UPF, IMIM)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Genetics and Genomics of Vegetable Crops and Rosaceae (CRAG)
- Genomics of Individuality (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Laboratory of Relational Algorithmics, Complexity and Learnability (UPC)
- Mathematical Modeling of Metabolic Processes (UdL)
- Multicellgenome Lab (UPF, UB, CSIC)
- Regulatory Genomics (IGTP)
- Roche Diagnostics (Roche)
- Sequentia Biotech (SeqBio)
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Computational Genomics (38)
- Algorithms, Computational Biology, Complexity and Formal Methods (UPC)
- Bioinformatics of Genome Diversity (UAB)
- Biomedical Genomics (IRB Barcelona)
- Cancer genetics and epigenetics (IGTP)
- Cancer Genomics Group (VHIO)
- Centre Nacional d'Anàlisi Genòmica (CRG)
- Clinical Genomics Unit ()
- Comparative Bioinformatics (CRG)
- Comparative Genomics (UPF, CSIC)
- Computational & Mathematical Biology (CRM)
- Computational Biology of RNA processing (CRG)
- Computational Genomics (BSC)
- Computational Genomics Lab @ UB (UB)
- Computational RNA Biology group of GRIB (UPF, IMIM)
- Epigenetics of Endocrine Pancreatic Tumours (IGTP)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics group of GRIB (UPF, IMIM)
- Evolutionary Genomics Lab (UPF, CSIC)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Evolutionary Systems Biology (UPF, CSIC)
- Gene Function and Evolution lab (CRG)
- Genome Data Science (IRB Barcelona)
- Genomic and Epigenomic Variation in Disease (CRG)
- Genomics and Bioinformatics (IGTP)
- Genomics and Bioinformatics Service (UAB)
- Genomics and Disease (CRG)
- Genomics of Individuality (UPF, CSIC)
- Human Genome Diversity Group (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Made of Genes (MoG)
- Mathematical Modeling of Metabolic Processes (UdL)
- Molecular Modelling and Bioinformatics (UB, IRB Barcelona)
- Oncology Data Science Group (VHIO)
- Regulatory Genomics (IGTP)
- Sequentia Biotech (SeqBio)
- The CRG Bioinformatics Unit (CRG)
- Translational & Consumer Genomics Unit ()
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Genetic Variation Analysis (17)
- Cancer genetics and epigenetics (IGTP)
- Centre Nacional d'Anàlisi Genòmica (CRG)
- Clinical Genomics Unit ()
- Compositional and Spatial Data Analysis (UPC)
- Evolutionary and Functional Genomics Lab (UPF, CSIC)
- Evolutionary Genomics & Bioinformatics (UB)
- Evolutionary Genomics Lab (UPF, CSIC)
- Evolutionary Population Genetics Lab (UPF, CSIC)
- Evolutionary Systems Biology (UPF, CSIC)
- Functional Genomics group of GRIB (UPF, IMIM)
- Genome Data Science (IRB Barcelona)
- Genomics and Bioinformatics (IGTP)
- Genomics of Individuality (UPF, CSIC)
- Human Genome Diversity Group (UPF, CSIC)
- Laboratory of Genetic Ichthyology (UdG)
- Sequentia Biotech (SeqBio)
- The CRG Bioinformatics Unit (CRG)
Bioinformatics services offered
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Primary run analysis and quality control
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Alignment of sequencing reads to the reference sequence
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Variant calling and annotation pipelines, including SNVs, InDels and CNVs
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Proprietary variant filtration and prioritization tools.
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Proprietary genome assembly pipeline using shotgun genome sequencing and/or fosmid pool approaches.
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Proprietary genome annotation pipeline for coding and non-coding RNAs.
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Differential expression analysis pipeline including proprietary GEM-split-mapper and Flux Capacitor for gene and isoform quantification.
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Identification of gene fusions from transcriptome reads.
more information at