Research groups

Information System for Research in Primary Care (SIDIAP)

The SIDIAP databse was created in 2010 under the auspices of the Catalan Institute of Health (ICS) and the IDIAP Jordi Gol. Its main aims is to promote the development of research based on data from primary care electronic medical records and other complementary databases.

SIDIAP was designed to provide a valid and reliable database of selected information from clinical records of patients registered in primary care centres for use in biomedical research. SIDIAP contains data of anonymized patients' healthcare records for nearly six million people (approximately 80% of the Catalan population) registered in 287 primary care practices throughout Catalonia since 2005. It was previously shown that SIDIAP population is highly representative of the entire Catalan region in terms of geographic, age, and sex distributions.

SIDIAP includes data collected by health professionals during routine visits in primary care, including anthropometric measurements, clinical diagnoses, laboratory tests, treatments, hospital referrals, demographic and lifestyle information.

Main projects

  • 1.

    Effectiveness, safety and costs of thromboembolic prevention in patients with atrial fibrillation: Study ESC-FA.

    Main objective: to analyse the use of drugs in the treatment of non-valvular atrial fibrillation with special emphasis on antithrombotic drugs. Secondary objectives: To describe the current antithrombotic management: anticoagulants and/or antiplatelets. To evaluate the effectiveness of the different antithrombotic drugs in the clinical setting based on the incidence of stroke and its safety on the incidence of bleeding requiring hospitalisation. To estimate the annual cost per patient of the different antithrombotics. To describe the management of the rhythm and the ventricular rate and to estimate the annual costs per patient of their use. To analyze the effect of the marketing of dabigatran on the thromboembolic drugs use as well as its effectiveness, safety and costs. METHODOLOGY: retrospective cohort study of the treatment and characteristics of patients with atrial fibrillation. The study will be carried using the SIDIAP database containeig anonymized information of the medical history of 280 primary care teams of the Institut Català de la Salut (covering the 85% of the population). The effectiveness, safety and costs of antithrombotic drugs.

  • 2.

    Effectiveness of Antihypertensive Treatment Initiation in the Primary Prevention of Cardiovascular Events. EITEC project

    OBJETCTIVES: 1. Identify the level of baseline blood pressure, baseline cardiovascular risk and blood pressure reduction at which antihypertensive treatment is effective in relation to the ocrurrence of cardiovascular events in the general population, population >65 years, <40 years and diabetics. 2. Analyze the cost - effectiveness of antihypertensive treatment based on baseline blood pressure levels and baseline cardiovascular risk in general population, population >65 years, <40 years and diabetics. SUBJECTS: People without a history of vascular events receiving treatment in any public Primary Care Centre (Institut Català de la Salut). Data will be obtained from the Information System for the Development of Primary Care Research (SIDIAP). METHODOLOGY: First, we analyze a population cohort of new users of antihypertensives vs unexposed cohort to estimate: 1.- The hazard ratio of cardiovascular events, 2.- the prevalence of risk factors (baseline cardiovascular risk calculation). The study will include approximately 290,000 new users of antihypertensives in the period of the study and a ratio of 2 controls per case. The follow-up period will be seven years. Subsequently, we will build a Markov model for cost-utility analysis from cohort data and data costs from the perspective of the NHS. The analysis will be performed based on the ratio of incremental cost-effectiveness (ICER).

  • 3.

    Longitudinal analysis of multimorbidity and polypharmacy patterns in people over 65 years: Study of a cohort based on electronic medical records

    OBJECTIVES: 1) To identify multimorbidity individual patterns, polypharmacy and the combination of both over time in multimorbidity people; 2) To analyse the evolution of the of the combined patterns of multimorbidity and polypharmacy and their association with safety standards (preventable medication, advised against and therapeutic duplications), clinical markers and mortality. Design: Population-based prospective longitudinal study. Scope: Primary health centres of Catalonia. Period: 2012-2016. Sources of information: Information System for the Improvement of Research in Primary Care. Subjects: Patients years, estimated sample: 1,200,000 people. Variables: Health problems (CIAP2), medications, age, sex, socioeconomic index, number of visits, renal function, liver function and mortality. Statistical analysis: Analysis of multimorbidity and polypharmacy patterns and the combination of both for individuals through multiple correspondence analysis and cluster analysis algorithm with k-means. People with different combined patterns obtained at the initial moment, will be followed in time and drug safety, liver and kidney function and mortality will be compared using generalized mixed models and / or models generalized estimating equations. All analyses will be stratified by age and sex.

Website

Institutions

Bioinformatics expertise:

Group Leader:

Bonaventura Bolíbar

Contact:

Anna Moleras

Bioinformatics services offered

  • SIDIAP

    Computerised databases of primary care clinical records are widely used for epidemiological research. In Catalonia, the Information System for the Development of Research in Primary Care (SIDIAP) aims to promote the development of research based on high-quality validated data from primary care electronic medical records. SIDIAP was designed to provide a valid, reliable database of selected information obtained from the clinical records of patients registered with primary care centres belonging to the Catalan Public Health Service (Institut Català de la Salut, ICS) for use in biomedical research.

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