Call for PhD Position
- Centre / Institution:
- Institute for Health Science Research Germans Trias i Pujol
- Bioinformatics expertise:
- Bioinformatics of Disease and Treatment, Computational Genomics, Functional Genomics, Genetic Variation Analysis, Integrative Bioinformatics, Metabolomics, Population Genetics, Systems Biology and Networks
- genomic epidemiology, complex diseases, exposome, genetic and epigenetic systems biology, metabolomics
- More information:
- Download file
RESEARCH PROJECT DESCRIPTION
BACKGROUND: Low-grade systemic inflammation is a common hallmark in the most prevalent chronic diseases in adulthood. Environmental exposure is a risk factor in chronic diseases that constitute the greatest burden of the healthcare system in economically developed countries. OBJECTIVE: To define at a personal level the impact of exogenous exposure on inflammation markers through the use of massive, clinical, genomic and exposure data at the population level. METHODS: Phase I: Characterization of clinical diagnoses in a population cohort and identification of conditions with a high inflammatory component. Phase II: Integrated analysis of exposure and genomic data for evaluation of prevalent cases and incidents during the period (2010-2020) and development of risk models. Phase III: Evaluation and impact of risk models in inflammation markers for clinical use. RESULTS: Exogenous and endogenous exposure factors with unfavourable impact on inflammation will be identified for use as markers of the associated disease, its progression and control.
Research Group description:
The GCAT' Genomes for Life Project has as ultimate goal to define the genomic architecture of complex traits and diseases from a global approach, providing new insights into normal physiology and disease pathophysiology to help the precision medicine of complex common disorders. We want obtain the maximum of information from the minimum four letter code personal book.
GCAT cohort, is the population based cohort used for the proposed research project. This cohort is generated (currently ongoing for coming years) from the GCAT project. Composed of 20.000 participants, has characterized near 6.000 individuals with genomics, whole genome sequence data, SNP-array genome, and metabolomics data. Currently as part of the project we are developing tools for complete exposome (environmental factors) for the whole cohort. The GCAT objective is integrate new type of data in space and time to get a powerful population- omic-cohort.
The GCAT lab is a dry lab, small group looking for new active and passionate people dreaming to develop skills and knowledge in the field of genomics of complex diseases. GCAT lab has an active, diverse and expert "cloud" of collaborators in a multidisciplinary functional network; from public health and epidemiological risk assessment, environmental risk assessment, bio computational analysis, clinical translation to clinical register data mining. We develop our scientific task in direct collaboration with a scientific expertise from all complex diseases research landscape, to fertilize and apply new approaches for genome integration and analysis in the precision medicine of common disorders.
The GCAT Lab group is part of the Health Research Institute Germans Trias i Pujol (IGTP), in Can Ruti Campus, near Barcelona in the Badalona Hills.
We are looking for an outstanding student, good nature, bioinformatics/computational biology skills/ formation, and intrepid with interest to work in the analysis of cutting-edge high-throughput OMIC data generated from a Catalan-Spanish population-based cohort of 20.000 individuals. The candidate will be working in a collaborative environment with data analysts, genomic, environmental and epidemiology researchers focused on a project to analyze environmental-genomic impact on common disease aetiology and architecture; the GeoINF+ project has been granted by Spanish Ministry for the next three years. GeoInf+ (PI18/01512)
We are interested in students looking for develop his/her thesis and his/her life in the coming years in our city.
The candidate will develop the GEOINF+ proposal, developing his skills in the field, from currently available methodology for interpretation of genomic data, whole genome, array SNP data genome, exposome data (environmental captured data using cutting-edge technologies). Computational representation and simulation of genetic and genomic systems: population genetics, gene mapping, genetic and biochemical networks, genetic and epigenetic systems biology, signaling pathways, physiological or metabolic systems, integration of -omic datasets are some of the skills in which the candidate should be expert at the end of stage.
Desired skills and expertise
- Title of Graduate in Biology / Pharmacy / Medicine or similar.
- Provision to work in the area of genomic epidemiology of complex diseases
- Provision to work autonomously and in teams.
- Accredit good academic record, required to opt for competitive financing third year.
- Accredit a good level of English
Contract duration and other benefits
WHAT WE OFFER:
- Hours: Full time
- Salary: we offer a competitive salary commensurate with the qualifications and experience of the candidate
- The contract will start 01/jul/2019
Required information and contact
HOW TO APPLY:
Those interested should send a letter of motivation explaining their interests, their CV and referral contact by email to rrhh(ELIMINAR)@igtp.cat
PLEASE PUT THE REFERENCE CODE FOR THIS POSITION (2018/131) IN THE SUBJECT OF YOUR E-MAIL.
After a pre-selection of the candidatures, the best will be interviewed.
DEADLINE FOR APPLICATIONS:
The official institutional deadline is 31/DEC/2018 when a first pre-selection will take place. Recruitment may be extended until 31/JAN/2019 depending on whether candidate profiles received meet the expected requirements.